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More often than not, your book is going to be perfect bound. So making sure you follow the perfect binding margins when formatting your book is very important.
Let me give you a quick review of what perfect binding is, just in case you are new to the scene. Perfect binding is the most commonly used form of binding on paperback books. Pages are bound together with a glue adhesive rather than being sewn or stitched. It is also used to bind publications that are too thick to be stapled using the saddle-stitch method.
Here is an example of a perfect bound book...